Structure
HS-152, Inhibitor
HS-152
Purity
>98% (HPLC)
Synonyms
HS-152; HS152; HS 152; inhibitor
Purity/Purification
>98% (HPLC)
Target
E3 Ubiquitin Ligase
Receptor
E3 Ubiquitin Ligase
Chemical Name
4-chloro-N-((3-(4-methylpiperazine-1-carbonyl) phenyl) carbamoyl)-benzamide
SMILES
O=C(NC(NC1=CC=CC(C(N2CCN(C)CC2)=O)=C1)=O)C3=CC=C(Cl)C=C3
Molecular Formula
C20H21ClN4O3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HS-152, inhibitor
HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC50 4.4uM and 2.1uM, respectively); inhibits both SMURF1 and SMURF2 catalytic activities, effectively inhibits protrusive activity in HEK293T cells and blocks TGFbeta-induced epithelial-mesenchymal transition (EMT) in MDCK cells, similar to the effects on these processes caused by SMURF1 loss.
Product Categories/Family for HS-152, inhibitor
References
1. J Biol Chem. 2018 Dec 26. pii: jbc.RA118.003822. doi: 10.1074/jbc.RA118.003822.
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Product Notes
The HS-152 (Catalog #AAA3607004) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HS-152, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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