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Structure

AZ12799734, Inhibitor

AZ12799734

Purity
>98% (HPLC)
Synonyms
AZ12799734; AZ-12799734; AZ 12799734; inhibitor
Ordering
Purity/Purification
>98% (HPLC)
Target
TGFBR
Receptor
TGFBR
Chemical Name
4-((4-((2, 6-dimethylpyridin-3-yl)oxy)pyridin-2-yl)amino)benzenesulfonamide
SMILES
CC1=NC(=C(C=C1)OC2=CC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)N)C
Molecular Formula
C18H18N4O3S
CAS Number
1117684-36-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for AZ12799734, inhibitor
AZ12799734 (AZ-12799734) is a pan BMP/TGFbeta inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47nM, inhibits receptor-mediated phosphorylation of SMAD1 by ALK1, BMPR1A and BMPR1B and phosphorylation of SMAD2 by ALK4, TGFBR1 and ALK7; inhibits TGFbeta-induced migration in HaCaT cells.
Product Categories/Family for AZ12799734, inhibitor
References
1. Spender LC, et al. Mol Pharmacol. 2018 Nov 20. pii: mol.118.112946. doi: 10.1124/mol.118.112946.
2. Goldberg FW, et al. J Med Chem. 2009 Dec 10; 52 (23):7901-5.

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Product Notes

The AZ12799734 (Catalog #AAA3600425) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZ12799734, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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