Structure
HL001, Inhibitor
HL001
Purity
>98% (HPLC)
Synonyms
HL001; HL 001; inhibitor
Purity/Purification
>98% (HPLC)
Target
MDM2-p53
Receptor
MDM2-p53
Chemical Name
N-((9H-fluoren-9-yl)carbamoyl)-2, 6-dihydroxybenzamide
Molecular Formula
C21H16N2O4
CAS Number
1186371-31-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HL001, inhibitor
HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression; stabilizes p53 through inhibiting the MDM2-mediated p53 ubiquitination, and downregulates G3BP1 and induces ROS and DNA damage; selectively suppresses tumor growth in p53 wild-type NSCLC harboring p53-72R through disrupting interaction between MDM2 and p53-72R in a CypA-dependent manner; synergistically enhance tumor regression in orthotopic NSCLC mouse model combined with cisplatin.
Product Categories/Family for HL001, inhibitor
References
1. Lu W, et al. Oncogene. 2017 Aug 17; 36 (33):4719-4731.
2. Ni S, et al. J Med Chem. 2009 Sep 10; 52 (17):5295-8.
2. Ni S, et al. J Med Chem. 2009 Sep 10; 52 (17):5295-8.
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Product Notes
The HL001 (Catalog #AAA3600634) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HL001, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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