DAPT, inhibitor
DAPT
Purity
>98%
Synonyms
DAPT; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Bio-Activity
g-secretase inhibitor
Solubility
Soluble in DMSO (up to 18mg/ml)
Chemical Name
N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
CAS #
208255-80-5
Molecular Formula
C23H26F2N2O4
Preparation and Storage
Store at -20 degree C
Related Product Information for DAPT, inhibitor
DAPT is an inhibitor of gamma-secretase (IC50 in human primary neurons = 115 nM for total Abeta or 200 nM for Abeta42 specifically) (1). Oral consumption of DAPT in mice and rats has reduced the amount of Abeta in brain extract, cerebrospinal fluid and plasma (2,3). DAPT also blocks Notch signaling, promoting neuronal differentiation (4). DAPT has also been shown to enhance iPS cells without the KLF4 and CMYC oncogenes (5).
Product Categories/Family for DAPT, inhibitor
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Product Notes
The DAPT (Catalog #AAA556518) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DAPT, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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