Testing Data
((S)-Tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX)
Secretase, gamma Inhibitor IX, Inhibitor
Secretase, gamma Inhibitor IX (DAPT N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester)
Purity
Highly Purified98% (HPLC)
Synonyms
Secretase; gamma Inhibitor IX; gamma Inhibitor IX (DAPT N-[N-(3; 5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester); inhibitor
Purity/Purification
Highly Purified
98% (HPLC)
98% (HPLC)
Form/Format
Supplied as a lyophilized powder.
CAS Number
208255-80-5
Molecular Formula
C23H26F2N2O4
Solubility
DMSO (20mg/ml)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Testing Data
((S)-Tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX)
Testing Data
((S)-Tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX)
Related Product Information for Secretase, gamma Inhibitor IX, inhibitor
A cell-permeable dipeptide that inhibits y-secretase activity and suppresses Ab production (Ab total IC50=115nM; Ab42 IC50=200nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of an ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, APP695. Reported to reduce extracellular Ab plaques and intracellular Ab accumulation in 3xTgAD transgenic mice.
Product Categories/Family for Secretase, gamma Inhibitor IX, inhibitor
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Product Notes
The Secretase, gamma Inhibitor IX (Catalog #AAA655431) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Secretase, gamma Inhibitor IX, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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