Western Blot (WB)
(HERC6 antibody - N-terminal region validated by WB using hek293 cell lysate at 1:1000.HERC6 is supported by BioGPS gene expression data to be expressed in HEK293)
Rabbit HERC6 Polyclonal Antibody | anti-HERC6 antibody
HERC6 antibody - N-terminal region
Western Blot (WB)
(HERC6 antibody - N-terminal region validated by WB using hek293 cell lysate at 1:1000.HERC6 is supported by BioGPS gene expression data to be expressed in HEK293)
Western Blot (WB)
(HERC6 antibody - N-terminal region validated by WB using hek293 cell lysate at 1:1000.HERC6 is supported by BioGPS gene expression data to be expressed in HEK293)
Western Blot (WB)
(WB Suggested Anti-HERC6 Antibody Titration: 0.2-1 ug/mlPositive Control: ACHN cell lysate)
Western Blot (WB)
(WB Suggested Anti-HERC6 Antibody Titration: 0.2-1 ug/mlPositive Control: ACHN cell lysate)
Target Description: HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
NCBI and Uniprot Product Information
NCBI Description
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Uniprot Description
HERC6: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ubiquitin-protein transferase activity
Biological Process: hemopoietic progenitor cell differentiation; protein polyubiquitination
Research Articles on HERC6
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Product Notes
The HERC6 herc6 (Catalog #AAA3206777) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HERC6 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HERC6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the HERC6 herc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LSKDSQVFSW GKNSHGQLGL GKEFPSQASP QRVRSLEGIP LAQVAAGGAH. It is sometimes possible for the material contained within the vial of "HERC6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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