Rabbit anti-Rat LRP1 Polyclonal Antibody | anti-LRP1 antibody

LRP1 Antibody: ATTO 390

Cat. Num. AAA8001544

• Gene Names: LRP1; APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1
• Reactivity: Rat
• Applications: Western Blot
• Purity: Peptide Affinity Purified
• Synonyms: LRP1; Polyclonal Antibody; LRP1 Antibody: ATTO 390; Rabbit Anti-Human LRP-1 Polyclonal; LRPICD Antibody; APOER Antibody; LRP-85 Antibody; LRP1 Antibody; A2MR Antibody; APR Antibody; Alpha-2-macroglobulin receptor Antibody; Apolipoprotein E receptor Antibody; Prolow-density lipoprotein receptor-related protein 1 Antibody; LRP-515 Antibody; LRP-1 Antibody; CD_antigen: CD91 Antibody; anti-LRP1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Detects 80 kDa, 50 kDa. Band at 80 kDa is a membrane spanning subunit, 50 kDa may be a degradation product.
• Purity/Purification: Peptide Affinity Purified
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 4544

• Applicable Applications for anti-LRP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Target: LRP-1
• Immunogen: Synthetic peptide from the mid-protein of Human Low-density lipoprotein receptor-related protein 1 (aa. 2880-2980)
• Immunogen Species: Human
• Cellular Localization: Cell Membrane; Single-Pass Type I Membrane Protein; Membrane; Coated Pit
• Conjugate: ATTO 390
• Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
• Tissue Specificity: Most abundant in liver, brain and lung.
• Preparation and Storage: Store at -20 degree C.

Western Blot (WB)

(Western blot analysis of Rat Kidney showing detection of 504.6 kDa LRP-1 protein using Rabbit Anti-LRP-1 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Rat Kidney. Load: 15 ug. Block: 5% Skim Milk powder in TBST. Primary Antibody: Rabbit Anti-LRP-1 Polyclonal Antibody at 1:1000 for 2 hours at RT with shaking. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:5000 for 1 hour at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: 504.6 kDa. Other Band(s): 80 kDa, 50 kDa.)

Product Categories/Family for anti-LRP1 antibody

Antibodies; Neuroscience; Neurodegeneration; Alzheimer's Disease; Cardiovascular System; Blood; Cancer; Apoptosis; Cancer Metabolism; Cardiovascular System; Atherosclerosis; Cancer; Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 126012562
• NCBI GeneID: 4035
• NCBI Accession #: NP_002323.2
• NCBI GenBank Nucleotide #: NM_002332.2
• UniProt Accession #: Q07954; Q2PP12; Q86SW0; Q8IVG8
• Molecular Weight: 31,631 Da
• NCBI Official Full Name: prolow-density lipoprotein receptor-related protein 1 preproprotein
• NCBI Official Synonym Full Names: LDL receptor related protein 1
• NCBI Official Symbol: LRP1
• NCBI Official Synonym Symbols: APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1
• NCBI Protein Information: prolow-density lipoprotein receptor-related protein 1
• UniProt Protein Name: Prolow-density lipoprotein receptor-related protein 1
• Protein Family: Low-density lipoprotein receptor-related protein
• UniProt Gene Name: LRP1
• UniProt Synonym Gene Names: A2MR; APR; A2MR; APOER; LRP-85; LRP-515; LRPICD

NCBI Description

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

Uniprot Description

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).