Structure
CPTH6 hydrobromide, Inhibitor
CPTH6 hydrobromide
Purity
>98% (HPLC)
Synonyms
CPTH6 hydrobromide; inhibitor
Purity/Purification
>98% (HPLC)
Target
HAT
Receptor
HAT
Chemical Name
(E)-4-(4-chlorophenyl)-2-(2-(3-methylcyclopentylidene)hydrazinyl)thiazole hydrobromide
Molecular Formula
C15H17BrClN3S
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CPTH6 hydrobromide, inhibitor
CPTH6 hydrobromide is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor; CPTH6 exerts a significant inhibitory effect on HAT activity of both pCAF and Gcn5, whereas it does not affect p300 and CBP HAT activity; decrease acetylation of histone H3 specifically at lysine 18 in a dose-dependent fashion, does not affect H3 histone methylation at lysines 9 and 4; induces cell-cycle perturbation and apoptosis in AML cells, induces differentiation in AML and neuroblastoma cells; impairs autophagy and reduces autophagosome turnover through an impairment of their degradation pathway.
Product Categories/Family for CPTH6 hydrobromide, inhibitor
References
1. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15; 18 (2):475-86.
2. Ragazzoni Y, et al. Cell Death Dis. 2013 Mar 7; 4:e524.
3. Di Martile M, et al. Oncotarget. 2016 Mar 8; 7 (10):11332-48.
4. Chimenti F, et al. J Med Chem. 2009 Jan 22; 52 (2):530-6.
2. Ragazzoni Y, et al. Cell Death Dis. 2013 Mar 7; 4:e524.
3. Di Martile M, et al. Oncotarget. 2016 Mar 8; 7 (10):11332-48.
4. Chimenti F, et al. J Med Chem. 2009 Jan 22; 52 (2):530-6.
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Product Notes
The CPTH6 hydrobromide (Catalog #AAA3607041) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CPTH6 hydrobromide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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