Structure
CO-1686 hydrobromide, Inhibitor
CO-1686 hydrobromide
Purity
>98% (HPLC)
Synonyms
CO-1686 hydrobromide; Rociletinib hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=59mg/mL
Target
EGFR
Receptor
EGFR
Chemical Name
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide(1:1)
SMILES
CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC.Br
Molecular Formula
C27H29BrF3N7O3
CAS Number
1446700-26-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CO-1686 hydrobromide, inhibitor
A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5nM for EGFR L858R/T790M; shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1uM; orally bioavailable. Breast Cancer Phase 2 Clinical
Product Categories/Family for CO-1686 hydrobromide, inhibitor
References
1. Walter AO, et al. Cancer Discov. 2013 Dec; 3 (12):1404-15.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun; 13 (6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30; 372 (18):1700-9.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun; 13 (6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30; 372 (18):1700-9.
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Product Notes
The CO-1686 hydrobromide (Catalog #AAA3601900) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CO-1686 hydrobromide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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