Cisplatin, Inhibitor

Cisplatin

Cat. Num. AAA384517

• Purity: >98%
• Synonyms: Cisplatin; cisplatinum; CDDP; cis-diamminedichloroplatinum(II); inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 33.32 mL (1 mg); 166.61 mL (5 mg); 333.22mL (10 mg); 0.5 mM: 6.66 mL (1 mg); 33.32 mL (5 mg); 66.64 mL (10 mg); 1 mM: 3.33 mL (1 mg); 16.66 mL (5 mg); 33.32 mL (10 mg); 5 mM: 0.67 mL (1 mg); 3.33 mL (5 mg); 6.66 mL (10 mg) (varies by lot)

• CAS Number: 15663-27-1
• Formula: Cl2H4N2Pt
• SMILES: N.N.Cl[Pt+2]Cl
• Targets: DNA; synthesis; (Tumor Cells)
• Solubility (DMSO): 60 mg/mL (199.96 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20°C 3 years Powder

Chemical Structure

Related Product Information for Cisplatin, inhibitor

Cisplatin was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

References

Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408