Mouse anti-Human HDAC4 Monoclonal Antibody | anti-HDAC4 antibody

Anti-HDAC4 Antibody (clone 2B11)

Cat. Num. AAA2400633

• Gene Names: HDAC4; HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified from ascites by Protein A
• Synonyms: HDAC4; Monoclonal Antibody; Anti-HDAC4 Antibody (clone 2B11); Rabbit Polyclonal (IgG) to Human HDAC4; BDMR; AHO3; Histone deacetylase A; HD4; HA6116; HDAC-A; HDACA; Histone deacetylase 4; HDAC-4; KIAA0288; anti-HDAC4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, k
• Clone Number: 2B11
• Specificity: Human HDAC4
• Purity/Purification: Purified from ascites by Protein A
• Form/Format: PBS, pH 7.4
• Sequence Length: 1084

• Applicable Applications for anti-HDAC4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: IHC-P: 5-10 ug/ml; WB: 1:500-1:1000
• Immunogen: HDAC4 (NP_006028, 551 a.a. ~ 648 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C or lower.; Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-HDAC4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Antibody Western blot of HDAC4 expression in Jurkat.)

ELISA (EIA)

(Detection limit for recombinant GST tagged HDAC4 is approximately 0.1 ng/ml as a capture antibody.)

Related Product Information for anti-HDAC4 antibody

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylationgives a tag for epigenetic repression and plays an important role intranscriptional regulation, cell cycle progression and developmentalevents. Histone deacetylases act via the formation of large multiproteincomplexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Product Categories/Family for anti-HDAC4 antibody

Histone Deacetylase

NCBI and Uniprot Product Information

• NCBI GI #: 153085395
• NCBI GeneID: 9759
• NCBI Accession #: NP_006028.2
• NCBI GenBank Nucleotide #: NM_006037.3
• UniProt Accession #: P56524; Q86YH7; Q9UND6; E9PGB9; F5GX36
• Molecular Weight: 106,367 Da
• NCBI Official Full Name: histone deacetylase 4
• NCBI Official Synonym Full Names: histone deacetylase 4
• NCBI Official Symbol: HDAC4
• NCBI Official Synonym Symbols: HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
• NCBI Protein Information: histone deacetylase 4
• UniProt Protein Name: Histone deacetylase 4
• UniProt Gene Name: HDAC4
• UniProt Synonym Gene Names: KIAA0288; HD4

NCBI Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

Uniprot Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).