Structure
CCT-251236, Inhibitor
CCT-251236
Purity
>98% (HPLC)
Synonyms
CCT-251236; CCT251236; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=150mg/mL (271.43mM)
Target
HSP
Receptor
HSP
Chemical Name
N-(5-(2, 3-dihydrobenzo[b][1, 4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
SMILES
O=C(C1=CC(C=CC(OCCN2CCCC2)=N3)=C3C=C1)NC4=CC(NC(C5=CC(OCCO6)=C6C=C5)=O)=CC=C4C
Molecular Formula
C32H32N4O5
CAS Number
1693731-40-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CCT-251236, inhibitor
A potent, orally available Pirin ligand (Ki=28nM), blocks the HSF1-mediated induction of both HSP72 and HSP27; inhibits the induction of HSP72 at the mRNA level, blocks the induction of HSPA1A gene expression with IC50 of 40nM, inhibits SK-OV-3 cells proliferation with GI50 of 1.1nM; displays efficacy in a human ovarian carcinoma xenograft model.
Product Categories/Family for CCT-251236, inhibitor
References
1. Cheeseman MD, et al. J Med Chem. 2017 Jan 12; 60 (1):180-201.
2. Chessum NEA, et al. J Med Chem. 2017 Dec 14. doi: 10.1021/acs.jmedchem.7b01406.
2. Chessum NEA, et al. J Med Chem. 2017 Dec 14. doi: 10.1021/acs.jmedchem.7b01406.
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Product Notes
The CCT-251236 (Catalog #AAA3602581) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CCT-251236, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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