Structure
BIX-01294, inhibitor
BIX-01294
Purity
99.31%
Synonyms
BIX-01294; inhibitor
Purity/Purification
99.31%
Form/Format
Solid. Powder
Solubility
DMSO: 98mg/mL (163.33mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C28H38N6O2
SMILES
COc1cc2nc(N3CCCN(C)CC3)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC
CAS Number
935693-62-2
Target & IC50
G9a: ic50 1.9uM
Cell Research
On the first day, cells were seeded in 96 well plates. Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well. After treatment,by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for BIX-01294, inhibitor
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 uM).
Product Categories/Family for BIX-01294, inhibitor
References
Cui J, Sun W, Hao X, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells[J]. Cancer Cell International, 2015, 15(1):4.
Cui J, Sun W, Hao X, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells[J]. Cancer Cell International, 2015, 15(1):4.
Homon C A, O'Sullivan R, August E M, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.[J]. Molecular Cell, 2007, 25(3):473-481.
Homon C A, O'Sullivan R, August E M, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.[J]. Molecular Cell, 2007, 25(3):473-481.
Cui J, Sun W, Hao X, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells[J]. Cancer Cell International, 2015, 15(1):4.
Homon C A, O'Sullivan R, August E M, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.[J]. Molecular Cell, 2007, 25(3):473-481.
Homon C A, O'Sullivan R, August E M, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.[J]. Molecular Cell, 2007, 25(3):473-481.
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Product Notes
The BIX-01294 (Catalog #AAA5758587) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIX-01294, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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