Structure
BI-2536, Inhibitor
BI-2536
Purity
>98% (HPLC)
Synonyms
BI-2536; BI 2536; BI2536; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PLK
Receptor
Met; PI3Kalpha; PLK1; PLK2; PLK3
Chemical Name
Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5, 6, 7, 8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)
SMILES
O=C(NC1CCN(C)CC1)C2=CC=C(NC(N=C3N(C4CCCC4)[C@@H]5CC)=NC=C3N(C)C5=O)C(OC)=C2
Molecular Formula
C28H39N7O3
CAS Number
755038-02-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BI-2536, inhibitor
A potent and selective inhibitor of PLK1 with IC50 of 0.83nM; also weakly inhibits the activities of PLK2 and PLK3 (IC50=3.5nM and 9.0nM, respectively), displays >1,000-fold selectivity to a panel of 63 other protein kinases; causes a mitotic arrest and induces apoptosis in human cancer cell lines, inhibits growth of human tumor xenografts in nude mice and induces regression of large tumors with well-tolerated intravenous dose regimens; also inhibits BRD4 with IC50 of 25nM. Blood Cancer Phase 2 Clinical
Product Categories/Family for BI-2536, inhibitor
References
1. Steegmaier M, et al. Curr Biol. 2007 Feb 20; 17 (4):316-22. Epub 2007 Feb 8.
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18; 6 (7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1; 69 (5):1916-23.
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18; 6 (7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1; 69 (5):1916-23.
Similar Products
Product Notes
The BI-2536 (Catalog #AAA3605868) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BI-2536, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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