Structure
iCRT-3, Inhibitor
iCRT-3
Purity
>98% (HPLC)
Synonyms
iCRT-3; iCRT3; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 150mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Beta-catenin
Receptor
Wnt, Wnt/beta-catenin
Chemical Name
2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide
SMILES
O=C(NCCC1=CC=CC=C1)CSCC2=C(C)OC(C3=CC=C(CC)C=C3)=N2
Molecular Formula
C23H26N2O2S
CAS Number
901751-47-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for iCRT-3, inhibitor
iCRT-3 is a selective, cell-permeable beta-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2nM; interferes with beta-cat-TCF4 interaction via direct beta-catenin (beta-cat) binding, inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25-75uM); selectively inhibits the proliferation of HCT116 (75uM), HT29 (75uM), and several primary human colon cancer cultures (6.25-100ug/ml).
Product Categories/Family for iCRT-3, inhibitor
References
1. Lee E, et al. Proc Natl Acad Sci U S A. 2013 Sep 24; 110 (39):15710-5.
2. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12; 108 (15):5954-63.
2. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12; 108 (15):5954-63.
Similar Products
Product Notes
The iCRT-3 (Catalog #AAA3606479) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "iCRT-3, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
