ATM-3507 trihydrochloride, Inhibitor | ATM-3507, inhibitor

ATM-3507 trihydrochloride

Purity

98.00%

Synonyms

ATM-3507 trihydrochloride; ATM-3507; inhibitor

Ordering
Cat. Num. AAA5752733 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

DMSO: 250mg/mL (346.66mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C37H49Cl3FN5O2

SMILES

O=C(C1=CC=CC(OC2=CC3=C(N(CCCN4CCN(C)CC4)C(C)=C3C)C=C2)=C1)N5CCN(CCC6=CC=C(F)C=C6)CC5.Cl.Cl.Cl

Target & IC50

tropomyosin, in human melanoma celllines: ic50 3.83-6.84uM

In Vitro

The maximal tolerance dose (MTD) for TR100 and ATM-3507 is 60 and 150mg/kg, respectively. The median survival of mice increased from 18 days for mice treated with ATM-3507 to more than 49 days for mice treated with the combination. It is also found that twice-weekly intravenous administration of ATM-3507 also shows combination efficacy. The impact of each treatment,or the combination of body weight is minimal. Drug levels are measured following the intravenous administration of ATM-3507 at 30mg/kg in Balb/c mice (n=3 per time point). The mean half-life of ATM-3507 is 5.01 hrs for the terminal elimination phase. The mean AUC0-t in the plasma is 14,548ng/h/mL. The Cmax of ATM-3507 is 5,758ng/mL and the t1/2 is 5.01 hours. The observed plasma clearance and volume of distribution at steady state of ATM-3507 is 33.8mL/min/kg and 7.23L/kg, respectively.

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Related Product Information for ATM-3507, inhibitor

ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84uM in human melanoma cell lines).

References

Currier MA, et al. Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.Mol Cancer Ther. 2017 Aug;16(8):1555-1565.
Currier MA, et al. Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.Mol Cancer Ther. 2017 Aug;16(8):1555-1565.

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Product Notes

The ATM-3507 (Catalog #AAA5752733) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ATM-3507 trihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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ATM-3507 trihydrochloride, Inhibitor | ATM-3507, inhibitor