Structure
CM-579 trihydrochloride, Inhibitor | CM-579, inhibitor
CM-579 trihydrochloride
Purity
98.00%
Synonyms
CM-579 trihydrochloride; CM-579; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 125mg/mL (207.63mM) Need ultrasonic
Methanol: 75mg/mL (124.58mM) Need ultrasonic
H2O: 37.5mg/mL (62.29mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Methanol: 75mg/mL (124.58mM) Need ultrasonic
H2O: 37.5mg/mL (62.29mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C29H43Cl3N4O3
SMILES
CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl
Target & IC50
DNA Methyltransferase: ic50 32nM
DNMT1: ic50 1.5nM (kd)
DNMT3A: ic50 92nM
DNMT3B: ic50 1000nM
G9a: ic50 16nM
DNMT1: ic50 1.5nM (kd)
DNMT3A: ic50 92nM
DNMT3B: ic50 1000nM
G9a: ic50 16nM
In Vitro
The Kd of CM-579 for DNMT1 is 1.5nM, CM-579 also inhibits DNMT3A and DNMT3B (IC50s: 92nM and 1000nM).
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for CM-579, inhibitor
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16nM, 32nM) with potent in vitro cellular activity in a wide range of cancer cells.
Product Categories/Family for CM-579, inhibitor
References
San Jose-Eneriz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
San Jose-Eneriz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
San Jose-Eneriz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
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Product Notes
The CM-579 (Catalog #AAA5752932) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CM-579 trihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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