Structure
BAY-299, inhibitor
BAY-299
Purity
98.00%
Synonyms
BAY-299; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 25mg/mL (58.21mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C25H23N3O4
SMILES
O=C(N1C2=C(C)C=C(N(C)C3=O)C(N3C)=C2)C4=CC=C(CCCO)C5=C4C(C1=O)=CC=C5
CAS Number
2080306-23-4
Target & IC50
BRPF2 BD: ic50 67nM
BRPF1 BD: ic50 3150nM
BRPF3 BD: ic50 5550nM
TAF1 BD2: ic50 8nM
TAF1L BD2: ic50 106nM
BRPF1 BD: ic50 3150nM
BRPF3 BD: ic50 5550nM
TAF1 BD2: ic50 8nM
TAF1L BD2: ic50 106nM
In Vitro
In vivo blood clearance is as anticipated based on rat liver microsome values but lower than expected based on hepatocyte data[1]. Studies of the in vivo pharmacokinetic properties of BAY-299 in rat reveal that blood clearance is low (ca. 17% of hepatic blood flow), volume of distribution in steady-state high, terminal half-life long to very long (t1/2=10 h), and bioavailability high (F=73%).
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for BAY-299, inhibitor
BAY-299 is a very potent inhibitor. For BRPF2 bromodomains (BD), TAF1 BD2, TAF1L BD2, the IC50s vanlues are 67nM, 8nM, and 106nM, respectively.
References
Bouche L, et al. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem. 2017 May 11;60(9):4002-4022.
Bouche L, et al. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem. 2017 May 11;60(9):4002-4022.
Bouche L, et al. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem. 2017 May 11;60(9):4002-4022.
Similar Products
Product Notes
The BAY-299 (Catalog #AAA5754582) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY-299, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
