Structure
ABD345, Inhibitor
ABD345
Purity
>98% (HPLC)
Synonyms
ABD345; ABD-345; ABD 345; inhibitor
Purity/Purification
>98% (HPLC)
Target
NF-kappaB
Receptor
NF-kappaB
Chemical Name
1-(2', 4'-Difluoro-2-methyl[1, 1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone
Molecular Formula
C19H20F2O2
CAS Number
1055896-51-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ABD345, inhibitor
ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-kappaB and MAPK activation and inflammation; inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7uM) without any effects on bone marrow macrophage viability; inhibits RANKL-induced phosphorylation of IkappaB and ERK in M-CSF-dependent bone marrow macrophage cultures; inhibits both RANKL- and TNF-induced NF-kappaB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.
Product Categories/Family for ABD345, inhibitor
References
1. Coste E, et al. Ann Rheum Dis. 2015 Jan; 74 (1):220-6.
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Product Notes
The ABD345 (Catalog #AAA3600255) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ABD345, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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