Structure
Helenalin Biochemical
Helenalin
Purity
>98% (HPLC)
Synonyms
Helenalin; NSC 85236; Helenalin biochemical
Purity/Purification
>98% (HPLC)
Target
NF-kappaB
Receptor
NF-kappaB
Chemical Name
3, 3aS, 4S, 4aR, 7aR, 8R, 9, 9aR-octahydro-4-hydroxy-4a, 8-dimethyl-3-methylene-azuleno[6, 5-b]furan-2, 5-dione
SMILES
C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2
Molecular Formula
C15H18O4
CAS Number
6754-13-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Helenalin biochemical
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-kappaB signaling pathway; ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-kappaB signaling (53.7 +/- 14.1% NF-kappaB activity at 2.5uM); suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.
Product Categories/Family for Helenalin biochemical
References
1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20; 12 (1):102-113.
2. Chen S, et al. Cell Death Dis. 2017 Mar 30; 8 (3):e2710.
3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11; 12:93.
2. Chen S, et al. Cell Death Dis. 2017 Mar 30; 8 (3):e2710.
3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11; 12:93.
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Product Notes
The Helenalin (Catalog #AAA3605578) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Helenalin, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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