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ILDR2 recombinant protein
Recombinant Human ILDR2 (C-Fc)
Gene Names
ILDR2; C1orf32; dJ782G3.1
Purity
>95% as determined by reducing SDS-PAGE
Synonyms
ILDR2; Recombinant Human ILDR2 (C-Fc); Angulin-3; C1orf32; Dbsm1; DJ782G3.1; immunoglobulin-like domain containing receptor 2; LISCH-Like; ILDR2 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE
Form/Format
Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
Sequence
Leu21-Glu186
Species
Human
Tag
C-Fc
Endotoxin
<1.0EU per ug as determined by the LAL method.
Protein Construction
Recombinant Human Immunoglobulin-like Domain-containing Receptor 2 is produced by our Mammalian expression system and the target gene encoding Leu21-Glu186 is expressed with a Fc tag at the C-terminus.
Preparation and Storage
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
This product is provided as lyophilized powder which is shipped with ice packs.
This product is provided as lyophilized powder which is shipped with ice packs.
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SDS-Page
Related Product Information for ILDR2 recombinant protein
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasis. The human ILDR2 lumenal domain shares a 99% and 98% homology with the mouse and rat respectively. The human gene encoding ILDR2 is located in a region on Chr1q23-25 that has been associated with type 2 diabetes. ILDR2 plays critical roles in hepatic clearance of lipoproteins and in lipid homeostasis. ILDR2 regulates human dendritic cells (DC2 cells, a subpopulation of polarized DCs that promotes Th2 differentiation). Recent publications reported that ILDR2 displayed negative regulatory functions on human and mouse T cells in various experimental systems. Fusion protein of ILDR2 lumenal domain with an Fc fragment, displays therapeutic effects in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA). ILDR2 represents a novel B7-like ligand that exerts negative immune modulation via interaction with a putative counterpart receptor expressed on activated T cells.
Product Categories/Family for ILDR2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
71,200 Da
NCBI Official Full Name
immunoglobulin-like domain-containing receptor 2
NCBI Official Synonym Full Names
immunoglobulin like domain containing receptor 2
NCBI Official Symbol
ILDR2
NCBI Official Synonym Symbols
C1orf32; dJ782G3.1
NCBI Protein Information
immunoglobulin-like domain-containing receptor 2
UniProt Protein Name
Immunoglobulin-like domain-containing receptor 2
Protein Family
UniProt Gene Name
ILDR2
UniProt Synonym Gene Names
C1orf32
Uniprot Description
May be involved in lipid homeostasis and ER stress pathways.
Research Articles on ILDR2
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Product Notes
The ILDR2 ildr2 (Catalog #AAA2569067) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Leu21-Glu1 86. It is sometimes possible for the material contained within the vial of "ILDR2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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