Leukocyte Ig-Like Receptor A5/LILRA5/CD85f) Biotinylated Recombinant Protein | LILRA5/CD85f recombinant protein

Recombinant Human Leukocyte Ig-Like Receptor A5/LILRA5/CD85f (C-6His-Avi) Biotinylated

Cat. Num. AAA2569189

• Gene Names: LILRA5; CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Leukocyte Ig-Like Receptor A5/LILRA5/CD85f) Biotinylated; Recombinant Human Leukocyte Ig-Like Receptor A5/LILRA5/CD85f (C-6His-Avi) Biotinylated; Leukocyte immunoglobulin-like receptor subfamily A member 5; CD85 antigen-like family member F; Immunoglobulin-like transcript 11; ILT-11; Leukocyte immunoglobulin-like receptor 9; LIR-9; CD85f; LILRA5; LILRB7 ; LILRA5/CD85f recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Gly42-Arg268

• Species: Human
• Tag: C-6His-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5 is produced by our Mammalian expression system and the target gene encoding Gly42-Arg268 is expressed with a 6His, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for LILRA5/CD85f recombinant protein

Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5 (LILRA5) is a member of the leukocyte immunoglobulin-like receptors (LILR), comprise a family of activating and inhibitory type immunoreceptors. LILRA5 consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. LILRA5 is expressed by monocytes, macrophages, and neutrophils. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

Product Categories/Family for LILRA5/CD85f recombinant protein

immunology

NCBI and Uniprot Product Information

• NCBI GI #: 32490553
• NCBI GeneID: 353514
• NCBI Accession #: NP_067073.1
• NCBI GenBank Nucleotide #: NM_021250.3
• UniProt Accession #: A6NI73; A6NHI3
• Molecular Weight: 31,538 Da
• NCBI Official Full Name: leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1
• NCBI Official Synonym Full Names: leukocyte immunoglobulin like receptor A5
• NCBI Official Symbol: LILRA5
• NCBI Official Synonym Symbols: CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7
• NCBI Protein Information: leukocyte immunoglobulin-like receptor subfamily A member 5
• UniProt Protein Name: Leukocyte immunoglobulin-like receptor subfamily A member 5
• UniProt Gene Name: LILRA5
• UniProt Synonym Gene Names: ILT11; LILRB7; LIR9; ILT-11; LIR-9

NCBI Description

The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.