SDS-PAGE
IL5Ra / CD125 recombinant protein
Recombinant Mouse IL5Ra / CD125 Protein (His tag)
Gene Names
Il5ra; Il5r; CD125; CDw125
Purity
> 95 % as determined by SDS-PAGE
Synonyms
IL5Ra / CD125; Recombinant Mouse IL5Ra / CD125 Protein (His tag); IL5Ra; Il5r; IL5Ra / CD125 recombinant protein
Host
Baculovirus-Insect Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 7.4.
Sequence Length
415
Application Notes
The recombinant mouse IL5Ra comprises 321 amino acids and has a predicted molecular mass of 36.8 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Asp 18
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for IL5Ra / CD125 recombinant protein
Background: Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. IL5RA (CD125) is a T-cell-derived cytokine which is particularly important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors.
Description: A DNA sequence encoding the mouse IL5Ra (P21183) (Met1-Val328) was expressed with a C-terminal polyhistidine tag.
Description: A DNA sequence encoding the mouse IL5Ra (P21183) (Met1-Val328) was expressed with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
46,989 Da
NCBI Official Full Name
interleukin-5 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 5 receptor, alpha
NCBI Official Symbol
Il5ra
NCBI Official Synonym Symbols
Il5r; CD125; CDw125
NCBI Protein Information
interleukin-5 receptor subunit alpha
UniProt Protein Name
Interleukin-5 receptor subunit alpha
UniProt Gene Name
Il5ra
UniProt Synonym Gene Names
Il5r; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA
Uniprot Description
IL5RA: This is the receptor for interleukin-5. The alpha chain binds to IL5. Belongs to the type I cytokine receptor family. Type 5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 6 E1|6 49.19 cM
Biological Process: inflammatory response to antigenic stimulus; regulation of interleukin-5 production
Research Articles on IL5Ra / CD125
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Product Notes
The IL5Ra / CD125 il5ra (Catalog #AAA2546639) is a Recombinant Protein produced from Baculovirus-Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse IL5Ra comprises 321 amino acids and has a predicted molecular mass of 36.8 kDa. The apparent molecular mass of the protein is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the IL5Ra / CD125 il5ra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL5Ra / CD125, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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