Interleukin-5/IL-5 Recombinant Protein | IL-5 recombinant protein

Recombinant Mouse Interleukin-5/IL-5 (C-6His)

Cat. Num. AAA2569324

• Gene Names: Il5; Il-5
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Interleukin-5/IL-5; Recombinant Mouse Interleukin-5/IL-5 (C-6His); Prolactin; PRL; IL-5 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Met21-Gly133

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Interleukin-5 is produced by our Mammalian expression system and the target gene encoding Met21-Gly133 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IL-5 recombinant protein

IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils.

NCBI and Uniprot Product Information

• NCBI GI #: 6754336
• NCBI GeneID: 16191
• NCBI Accession #: NP_034688.1
• NCBI GenBank Nucleotide #: NM_010558.1
• UniProt Accession #: P04401
• Molecular Weight: 15,410 Da
• NCBI Official Full Name: interleukin-5
• NCBI Official Synonym Full Names: interleukin 5
• NCBI Official Symbol: Il5
• NCBI Official Synonym Symbols: Il-5
• NCBI Protein Information: interleukin-5; B-cell growth factor II; BCGF-II; T-cell replacing factor; TRF; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor
• UniProt Protein Name: Interleukin-5
• UniProt Gene Name: Il5
• UniProt Synonym Gene Names: Il-5; IL-5; BCGF-II; TRF
• UniProt Entry Name: IL5_MOUSE

Uniprot Description

IL5: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. Belongs to the IL-5 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-5 receptor binding; growth factor activity; cytokine activity

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; positive regulation of JAK-STAT cascade; immune response; positive regulation of transcription factor activity; positive regulation of immunoglobulin secretion; positive regulation of eosinophil differentiation