Rabbit TEAD3 Polyclonal Antibody | anti-TEAD3 antibody

TEAD3 antibody - N-terminal region

Cat. Num. AAA3203995

• Gene Names: TEAD3; TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: TEAD3; Polyclonal Antibody; TEAD3 antibody - N-terminal region; anti-TEAD3 antibody

• Host: Rabbit
• Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity Purified
• Form/Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Sequence: Synthetic peptide located within the following region: MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIY
• Sequence Length: 435

• Applicable Applications for anti-TEAD3 antibody: Western Blot (WB)
• Homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 100%
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TEAD3
• Preparation and Storage: For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Host: RabbitTarget Name: TEAD3Sample Tissue: Human HepG2Antibody Dilution: 1.0ug/ml)

Western Blot (WB)

(WB Suggested Anti-TEAD3 Antibody Titration: 0.2-1 ug/mlPositive Control: Hela cell lysate)

Western Blot (WB)

(WB Suggested Anti-TEAD3 antibody Titration: 1 ug/mLSample Type: Human heart)

Related Product Information for anti-TEAD3 antibody

This is a rabbit polyclonal antibody against TEAD3. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: TEAD3 is a member of the transcriptional enhancer factor (TEF) family. The family members contain the TEA/ATTS DNA-binding domain. This member is preferentially expressed in placenta and transactivates the chorionic somatomammotropin gene enhancer. This gene encodes a member of the transcriptional enhancer factor (TEF) family. The family members contain the TEA/ATTS DNA-binding domain. This member is preferentially expressed in placenta and transactivates the chorionic somatomammotropin gene enhancer. The protein is encoded through the use of a non-AUG (ATA) translation initiation codon.This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.

Product Categories/Family for anti-TEAD3 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; DNA/RNA/Protein Interactions; Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 42490753
• NCBI GeneID: 7005
• NCBI Accession #: NP_003205
• NCBI GenBank Nucleotide #: NM_003214
• UniProt Accession #: Q99594
• Molecular Weight: 49kDa
• NCBI Official Full Name: transcriptional enhancer factor TEF-5
• NCBI Official Synonym Full Names: TEA domain transcription factor 3
• NCBI Official Symbol: TEAD3
• NCBI Official Synonym Symbols: TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
• NCBI Protein Information: transcriptional enhancer factor TEF-5
• UniProt Protein Name: Transcriptional enhancer factor TEF-5
• Protein Family: Transcriptional enhancer factor
• UniProt Gene Name: TEAD3
• UniProt Synonym Gene Names: TEAD5; TEF5; TEAD-3
• UniProt Entry Name: TEAD3_HUMAN

NCBI Description

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

Uniprot Description

TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: protein binding; DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; female pregnancy