Interleukin-36 gamma/IL-36 gamma/IL-1F9 Recombinant Protein | IL-36gamma/IL-1F9 recombinant protein

Recombinant Mouse Interleukin-36 gamma/IL-36 gamma/IL-1F9

Cat. Num. AAA2569326

• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Interleukin-36 gamma/IL-36 gamma/IL-1F9; Recombinant Mouse Interleukin-36 gamma/IL-36 gamma/IL-1F9; Interleukin-36 gamma; IL36G; IL-1-related protein 2; IL-1RP2; IL-1 epsilon; IL-1F9; Interleukin-1 homolog 1; IL-1H1; IL-36gamma/IL-1F9 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of 1M MOPS, 10 mM NaAc, 2 mM EDTA, 5% Trehalose, 0.02% Tween-20, pH7.6.
• Sequence: Gly13-Ser164

• Species: Mouse
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Interleukin-36 Gamma is produced by our E Coli expression system and the target gene encoding Gly13-Ser164 is expressed.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for IL-36gamma/IL-1F9 recombinant protein

Interleukin-36 gamma (IL-36gamma) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36alpha, beta, and gamma, formerly known as IL-1F6, F8, and F9 respectively. IL-36alpha has been detected in both neuronal and synovial tissue, whereas IL-36beta and IL-36gamma are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36beta and IL-36gamma stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36alpha is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). IL-36gamma plays an important role in communicating the cell death to surrounding cells.

NCBI and Uniprot Product Information

• NCBI GI #: 25008588
• UniProt Accession #: Q8R460; Q14BB6
• Molecular Weight: 18,733 Da
• NCBI Official Full Name: Interleukin-36 gamma
• UniProt Protein Name: Interleukin-36 gamma
• UniProt Gene Name: Il36g
• UniProt Synonym Gene Names: Il1f9; IL-1F9
• UniProt Entry Name: IL36G_MOUSE

Uniprot Description

Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T-cells and splenocytes.