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IL-33 recombinant protein

IL-33 (mouse), (recombinant) (SuperPack)

Gene Names
Il33; Il-33; Il1f11; NF-HEV; 9230117N10Rik
Purity
>=95% (SDS-PAGE)
Synonyms
IL-33; IL-33 (mouse); (recombinant) (SuperPack); IL-33 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Specificity
Binds to mouse and human ST2
Purity/Purification
>=95% (SDS-PAGE)
Form/Format
Lyophilized. Contains PBS
Concentration
0.1mg/ml after reconstitution (varies by lot)
Source Note
Untagged mouse IL-33 (aa 109-266)
Endotoxin
<0.1EU/ug purified protein (LAL test)
Reconstitution
Reconstitute with 100ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum
Preparation and Storage
Stable for at least 6 months after receipt when stored at -20 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice
Related Product Information for IL-33 recombinant protein
IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-kappaB and MAPK pathways. The mouse IL-33 protein is expressed with a prodomain (aa 1-108) which is cleaved to produce the 18kDa mature protein (109-266). Historical data has shown that IL-33 activates mouse and human ST2-dependent NF-kappaB pathway and induces IL-6 production in P815 mastocytoma cells and in bone marrow derived mast cells.
Product Categories/Family for IL-33 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
29,991 Da
NCBI Official Full Name
interleukin-33
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
Il33
NCBI Official Synonym Symbols
Il-33; Il1f11; NF-HEV; 9230117N10Rik
NCBI Protein Information
interleukin-33
UniProt Protein Name
Interleukin-33
UniProt Gene Name
Il33
UniProt Synonym Gene Names
IL-33
UniProt Entry Name
IL33_MOUSE

Uniprot Description

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: nucleus

Molecular Function: cytokine activity

Biological Process: defense response to virus; macrophage activation during immune response; microglial cell activation during immune response; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 2 type immune response; positive regulation of transcription from RNA polymerase II promoter

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Product Notes

The IL-33 il33 (Catalog #AAA566241) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL-33, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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