IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 Recombinant Protein | IL-1 R4 recombinant protein
Recombinant Mouse IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 Protein (C-Fc)
Gene Names
Il1rl1; T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4; Recombinant Mouse IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 Protein (C-Fc); Interleukin-1 receptor-like 1; Lymphocyte antigen 84; Protein ST2; Protein T1; Il1rl1; DER4; Fit-1; IL-1 R4; IL-1RL1; IL-33R; Ly84; ST2L; ST2V; suppression of tumorigenicity 2; IL-1 R4 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Sequence Positions
Ser27-Ala337
Sequence Length
567
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-Fc
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for IL-1 R4 recombinant protein
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor alpha chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-kappaB (NF-kappaB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 62.7 kDa
Actual Protein Molecular Mass: 90-110 kDa
Actual Protein Molecular Mass: 90-110 kDa
NCBI Official Full Name
interleukin-1 receptor-like 1 isoform a
NCBI Official Synonym Full Names
interleukin 1 receptor-like 1
NCBI Official Symbol
Il1rl1
NCBI Official Synonym Symbols
T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
NCBI Protein Information
interleukin-1 receptor-like 1
UniProt Protein Name
Interleukin-1 receptor-like 1
UniProt Gene Name
Il1rl1
UniProt Synonym Gene Names
Ly84; St2; Ste2
Uniprot Description
Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP (PubMed:18450470, PubMed:17675517). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (). Possibly involved in helper T-cell function.
Research Articles on IL-1 R4
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Product Notes
The IL-1 R4 il1rl1 (Catalog #AAA2553526) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Ser27-Ala337. It is sometimes possible for the material contained within the vial of "IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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