Interleukin-12 receptor subunit beta-1 (Il12rb1) Recombinant Protein | Il12rb1 recombinant protein

Recombinant Mouse Interleukin-12 receptor subunit beta-1 (Il12rb1), partial

Cat. Num. AAA1341728

• Gene Names: Il12rb1; CD212; IL-12R[b]
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin-12 receptor subunit beta-1 (Il12rb1); Recombinant Mouse Interleukin-12 receptor subunit beta-1 (Il12rb1); partial; Il12rb1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 20-565
• Sequence: Q LGASGPGDGC CVEKTSFPEG ASGSPLGPRN LSCYRVSKTD YECSWQYDGP EDNVSHVLWC CFVPPNHTHT GQERCRYFSS GPDRTVQFWE QDGIPVLSKV NFWVESRLGN RTMKSQKISQ YLYNWTKTTP PLGHIKVSQS HRQLRMDWNV SEEAGAEVQF RRRMPTTNWT LGDCGPQVNS GSGVLGDIRG SMSESCLCPS ENMAQEIQIR RRRRLSSGAP GGPWSDWSMP VCVPPEVLPQ AKIKFLVEPL NQGGRRRLTM QGQSPQLAVP EGCRGRPGAQ VKKHLVLVRM LSCRCQAQTS KTVPLGKKLN LSGATYDLNV LAKTRFGRST IQKWHLPAQE LTETRALNVS VGGNMTSMQW AAQAPGTTYC LEWQPWFQHR NHTHCTLIVP EEEDPAKMVT HSWSSKPTLE QEECYRITVF ASKNPKNPML WATVLSSYYF GGNASRAGTP RHVSVRNQTG DSVSVEWTAS QLSTCPGVLT QYVVRCEAED GAWESEWLVP PTKTQVTLDG LRSRVMYKVQ VRADTARLPG AWSHPQRFSF EVQIS
• Sequence Length: 546

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Il12rb1 recombinant protein

This protein is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 159110576
• NCBI GeneID: 16161
• NCBI Accession #: NP_032379.2
• NCBI GenBank Nucleotide #: NM_008353.2
• UniProt Accession #: Q60837; Q3UV59
• Molecular Weight: 81,788 Da
• NCBI Official Full Name: interleukin-12 receptor subunit beta-1
• NCBI Official Synonym Full Names: interleukin 12 receptor, beta 1
• NCBI Official Symbol: Il12rb1
• NCBI Official Synonym Symbols: CD212; IL-12R[b]
• NCBI Protein Information: interleukin-12 receptor subunit beta-1
• UniProt Protein Name: Interleukin-12 receptor subunit beta-1
• Protein Family: Interleukin-12 receptor
• UniProt Gene Name: Il12rb1
• UniProt Synonym Gene Names: Il12rb; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1

Uniprot Description

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.