Inducible T-Cell Costimulator Recombinant Protein | Icos recombinant protein

Recombinant Mouse Inducible T-Cell Costimulator Protein

Cat. Num. AAA2556775

• Gene Names: Icos; H4; CCLP; AILIM; CRP-1; Ly115
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Inducible T-Cell Costimulator; Recombinant Mouse Inducible T-Cell Costimulator Protein; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD28 and CTLA-4-like protein; CCLP; CD28-related protein 1; CRP-1; CD278; Icos; Ailim; Icos recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 200

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Glu21-Leu142
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Icos recombinant protein

Protein Construction: Recombinant Mouse Inducible T-cell Costimulator is produced by our Mammalian expression system and the target gene encoding Glu21-Leu142 is expressed with a 6His tag at the C-terminus.

Background: Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA4 and PD1. ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4. Mouse and human ICOS share approximately 72% amino acid identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. In addition, ICOS is more potent in the induction of IL-10 production, acytokine important for suppressive function of T regulatory cells.

NCBI and Uniprot Product Information

• NCBI GI #: 224809335
• NCBI GeneID: 54167
• NCBI Accession #: NP_059508.2
• NCBI GenBank Nucleotide #: NM_017480.2
• UniProt Accession #: Q9WVS0; Q9JL17
• Molecular Weight: Molecular Mass: 14.7kDa; Actual Protein Molecular Mass: 16-30kDa
• NCBI Official Full Name: inducible T-cell costimulator
• NCBI Official Synonym Full Names: inducible T cell co-stimulator
• NCBI Official Symbol: Icos
• NCBI Official Synonym Symbols: H4; CCLP; AILIM; CRP-1; Ly115
• NCBI Protein Information: inducible T-cell costimulator
• UniProt Protein Name: Inducible T-cell costimulator
• Protein Family: Inducible T-cell costimulator
• UniProt Gene Name: Icos
• UniProt Synonym Gene Names: Ailim; CCLP; CRP-1

Uniprot Description

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes ().