ICAM5 recombinant protein

ICAM5 Protein, Human, Recombinant (ECD, hFc Tag)

Cat. Num. AAA8122013

• Gene Names: ICAM5; TLN; TLCN
• Purity: >90% as determined by SDS-PAGE
• Synonyms: ICAM5; ICAM5 Protein; Human; Recombinant (ECD; hFc Tag); Human ICAM 5/Intercellular adhesion molecule 5 Protein (ECD; Fc Tag); TLCN Protein; TLN Protein; intercellular adhesion molecule 5; telencephalin; ICAM5 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu570

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Glu 32
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human ICAM5 (NP_003250.3)(Met1-Glu570) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 189571583
• NCBI GeneID: 7087
• NCBI Accession #: NP_003250.3
• NCBI GenBank Nucleotide #: NM_003259.3
• UniProt Accession #: Q9UMF0; Q9Y6F3
• Molecular Weight: 97,116 Da
• NCBI Official Full Name: intercellular adhesion molecule 5
• NCBI Official Synonym Full Names: intercellular adhesion molecule 5
• NCBI Official Symbol: ICAM5
• NCBI Official Synonym Symbols: TLN; TLCN
• NCBI Protein Information: intercellular adhesion molecule 5
• UniProt Protein Name: Intercellular adhesion molecule 5
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: ICAM5
• UniProt Synonym Gene Names: TLCN; TLN; ICAM-5
• UniProt Entry Name: ICAM5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

Uniprot Description

ICAM5: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). Belongs to the immunoglobulin superfamily. ICAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: integrin binding; protein binding

Biological Process: cell-cell adhesion; cell adhesion; phagocytosis