Human Protein Tyrosine Phosphatase Receptor Type S (PTPRS) RTU ELISA Kit | PTPRS rtu elisa kit

Human Protein Tyrosine Phosphatase Receptor Type S (PTPRS) ELISA Kit

Cat. Num. AAA4502124

• Gene Names: PTPRS; R-PTP-S; PTPSIGMA; R-PTP-sigma
• Reactivity: Human
• Synonyms: Protein Tyrosine Phosphatase Receptor Type S (PTPRS); Human Protein Tyrosine Phosphatase Receptor Type S (PTPRS) ELISA Kit; PTPR-S; PTPSIGMA; PTP SIGMA; Receptor-type tyrosine-protein phosphatase sigma; PTPRS rtu elisa kit

• Reactivity: Human
• Sequence Length: 1948

• Assay Type: Sandwich
• Samples: Tissue Homogenates, Cell Lysates or Other Biological Fluids.
• Detection Range: 0.781-50ng/mL
• Sensitivity: 0.27ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for PTPRS rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to PTPRS. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to PTPRS. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain PTPRS, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of PTPRS in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 104487006
• NCBI GeneID: 5802
• NCBI Accession #: NP_002841.3
• NCBI GenBank Nucleotide #: NM_002850.3
• UniProt Accession #: Q13332; O75255; O75870; Q15718; Q16341; Q2M3R7
• Molecular Weight: 168,394 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase S isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type S
• NCBI Official Symbol: PTPRS
• NCBI Official Synonym Symbols: R-PTP-S; PTPSIGMA; R-PTP-sigma
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase S
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase S
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRS
• UniProt Synonym Gene Names: R-PTP-S; R-PTP-sigma

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).