Valpha TCR recombinant antibody
Anti-Valpha TCR [34]
Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional Assay, Western Blot
Purity
Protein A Affinity Purified
Synonyms
Valpha TCR; Anti-Valpha TCR [34]; TCR variable alpha chain; T-cell receptor variable alpha chain; Valpha TCR recombinant antibody
Reactivity
Human
Isotype
Mouse IgG1, kappa
Clone Number
34
Specificity
This antibody binds to the T-cell receptor alpha chains.
Purity/Purification
Protein A Affinity Purified
Applicable Applications for Valpha TCR recombinant antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Western Blot (WB)
Application Notes
The antibody binds specifically to the recombinant and native variable domain of the alpha chain which comprises the T-cell receptor (TCR). The TCR is a disulfide-linked heterodimeric protein expressed on the surface of T-cells in complex with CD3 and zeta-chain molecules. The receptor functions in the recognition of MHC molecule and the subsequent activation of T-cells. The monoclonal antibody 34 Recognizes Valpha regions of TCRs expressed in the 85.33 arthritogenic T-cell hybridoma and can be used to analyse TCR V gene expression and for immunotherapy in T cell mediated autoimmunity.
Buffer Composition
PBS only with 0.02% Proclin 300.
Immunogen
Purified recombinant soluble 85.33 scTCR.
Chimeric Use Statement
This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for Valpha TCR recombinant antibody
Recombinant monoclonal antibody to Valpha TCR. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the scFv 34. This full-length, reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Product Categories/Family for Valpha TCR recombinant antibody
References
Popov S, Hubbard JG, Ward ES. A novel and efficient route for the isolation of antibodies that recognise T cell receptor V alpha(s). Mol Immunol. 1996 Apr; 33(6):493-502. PMID:8700165
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Product Notes
The Valpha TCR (Catalog #AAA488206) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Valpha TCR [34] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Valpha TCR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS), Western Blot (WB). The antibody binds specifically to the recombinant and native variable domain of the alpha chain which comprises the T-cell receptor (TCR). The TCR is a disulfide-linked heterodimeric protein expressed on the surface of T-cells in complex with CD3 and zeta-chain molecules. The receptor functions in the recognition of MHC molecule and the subsequent activation of T-cells. The monoclonal antibody 34 Recognizes Valpha regions of TCRs expressed in the 85.33 arthritogenic T-cell hybridoma and can be used to analyse TCR V gene expression and for immunotherapy in T cell mediated autoimmunity. Researchers should empirically determine the suitability of the Valpha TCR for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Valpha TCR, Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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