Testing Data
(Image: Western blot analysis indicated that concatamerized trimers remain intact. Total protein from oocytes injected with RNA for wild type P2X2 monomer, or trimer HH-HH-HH, HA-AA-AH, and AA-AA-HH was separated by SDS-PAGE under reducing conditions on a 4-12% gradient gel along with protein from uninjected oocytes. Immunoblot analysis was performed using a polyclonal antibody directed to an extracellular epitope of the human P2X2 receptor and ECL. The position of molecular mass standards (kDa) are shown on the left. In Western blots of similar gels, trimer HA-AH-HH gave a single band of the same size as the trimers shown here. DOI 10.1074/jbc.M504545200.)
P2X2 Antibody | anti-P2X2 antibody
P2X2, Control Peptide
Testing Data
(Image: Western blot analysis indicated that concatamerized trimers remain intact. Total protein from oocytes injected with RNA for wild type P2X2 monomer, or trimer HH-HH-HH, HA-AA-AH, and AA-AA-HH was separated by SDS-PAGE under reducing conditions on a 4-12% gradient gel along with protein from uninjected oocytes. Immunoblot analysis was performed using a polyclonal antibody directed to an extracellular epitope of the human P2X2 receptor and ECL. The position of molecular mass standards (kDa) are shown on the left. In Western blots of similar gels, trimer HA-AH-HH gave a single band of the same size as the trimers shown here. DOI 10.1074/jbc.M504545200.)
Testing Data
(Image: Western blot analysis indicated that concatamerized trimers remain intact. Total protein from oocytes injected with RNA for wild type P2X2 monomer, or trimer HH-HH-HH, HA-AA-AH, and AA-AA-HH was separated by SDS-PAGE under reducing conditions on a 4-12% gradient gel along with protein from uninjected oocytes. Immunoblot analysis was performed using a polyclonal antibody directed to an extracellular epitope of the human P2X2 receptor and ECL. The position of molecular mass standards (kDa) are shown on the left. In Western blots of similar gels, trimer HA-AH-HH gave a single band of the same size as the trimers shown here. DOI 10.1074/jbc.M504545200.)
Testing Data
(Image: Western blot analysis indicated that concatamerized trimers remain intact. Total protein from oocytes injected with RNA for wild type P2X2 monomer, or trimer HH-HH-HH, HA-AA-AH, and AA-AA-HH was separated by SDS-PAGE under reducing conditions on a 4-12% gradient gel along with protein from uninjected oocytes. Immunoblot analysis was performed using a polyclonal antibody directed to an extracellular epitope of the human P2X2 receptor and ECL. The position of molecular mass standards (kDa) are shown on the left. In Western blots of similar gels, trimer HA-AH-HH gave a single band of the same size as the trimers shown here. DOI 10.1074/jbc.M504545200.)
Testing Data
(Image: Western blot analysis indicated that concatamerized trimers remain intact. Total protein from oocytes injected with RNA for wild type P2X2 monomer, or trimer HH-HH-HH, HA-AA-AH, and AA-AA-HH was separated by SDS-PAGE under reducing conditions on a 4-12% gradient gel along with protein from uninjected oocytes. Immunoblot analysis was performed using a polyclonal antibody directed to an extracellular epitope of the human P2X2 receptor and ECL. The position of molecular mass standards (kDa) are shown on the left. In Western blots of similar gels, trimer HA-AH-HH gave a single band of the same size as the trimers shown here. DOI 10.1074/jbc.M504545200.)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
Uniprot Description
P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, ligand-gated; Channel, cation; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q24.33
Cellular Component: presynaptic membrane; cell surface; cell soma; integral to plasma membrane; postsynaptic density; apical plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex
Molecular Function: identical protein binding; copper ion binding; zinc ion binding; mercury ion binding; drug binding; ligand-gated ion channel activity; cadmium ion binding; purinergic nucleotide receptor activity; nickel ion binding; cobalt ion binding; phosphoinositide binding; ATP binding; ATP-gated cation channel activity
Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; protein heterooligomerization; generation of action potential; skeletal muscle fiber development; positive regulation of calcium-mediated signaling; detection of hypoxic conditions in blood by carotid body chemoreceptors; response to ATP; response to carbohydrate stimulus; behavioral response to pain; sensory perception of sound; response to hypoxia; neuromuscular synaptic transmission; protein homooligomerization; neuromuscular junction development
Disease: Deafness, Autosomal Dominant 41
Research Articles on P2X2
Similar Products
Product Notes
The P2X2 p2rx2 (Catalog #AAA555338) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The P2X2, Control Peptide reacts with Human, Primate, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's P2X2 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the P2X2 p2rx2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2X2, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
