C1, Inhibitor | SERPING1, inhibitor

Human C1 Inhibitor

Cat. Num. AAA136086

• Gene Names: SERPING1; C1IN; C1NH; HAE1; HAE2; C1INH
• Purity: >95% by SDS-PAGE analysis
• Synonyms: C1; Human C1 Inhibitor; C-1 Esterase Inhibitor; Human Plasma Human C1 Inhibitor; SERPING1; inhibitor

• Host: Human Plasma
• Purity/Purification: >95% by SDS-PAGE analysis
• Form/Format: Frozen Liquid-0.02M Potassium Phosphate; 0.25M NaCl; pH 7.0
• Concentration: 5.0 mg/ml (varies by lot)
• Sequence Length: 500

• Extinction Coefficient: 0.4
• Preparation and Storage: Store at -70 degree C.

Related Product Information for SERPING1, inhibitor

Human C1 Inhibitor (also known as plasma protease C1 inhibitor, C1 esterase inhibitor, C1-inhibiting factor, C1-INH, and C1INA) is a single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, plasmin, Factors XIa and XIIa. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the C1EI is non-functional. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE.

Product Categories/Family for SERPING1, inhibitor

Human C1 Inhibitor; Human Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 73858568
• NCBI GeneID: 710
• NCBI Accession #: NP_000053.2
• NCBI GenBank Nucleotide #: NM_000062.2
• UniProt Accession #: P05155; Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2
• Molecular Weight: 100000
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serpin family G member 1
• NCBI Official Symbol: SERPING1
• NCBI Official Synonym Symbols: C1IN; C1NH; HAE1; HAE2; C1INH
• NCBI Protein Information: plasma protease C1 inhibitor
• UniProt Protein Name: Plasma protease C1 inhibitor
• Protein Family: C1q-related factor
• UniProt Gene Name: SERPING1
• UniProt Synonym Gene Names: C1IN; C1NH; C1 Inh; C1Inh

NCBI Description

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Uniprot Description

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.