Mouse anti-Homo Sapiens C1 INH Monoclonal Antibody | anti-C1 INH antibody

C1 INH Mouse mAb

Cat. Num. AAA435466

• Gene Names: SERPING1; C1IN; C1NH; HAE1; HAE2; C1INH
• Reactivity: Homo Sapiens
• Applications: Western Blot, Immunoprecipitation, Flow Cytometry, Functional Assay
• Synonyms: C1 INH; Monoclonal Antibody; C1 INH Mouse mAb; anti-C1 INH antibody

• Host: Mouse
• Reactivity: Homo Sapiens
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 500

• Applicable Applications for anti-C1 INH antibody: Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:1000-1:5000; IP: 10 tests; FC/FACS: 1:100-1:200
• Source Note: This monoclonal antibody is produced by immunizing mice with a sythetic peptide(KLH coupled)corresponding to amino-terminal residues of C1 INH
• Preparation and Storage: Store at -20 degree C. Stable for one year from the date of shipment.

Western Blot (WB)

Related Product Information for anti-C1 INH antibody

C1 INH (C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation. The protein is an acute-phase protein that circulates in blood at levels of around 0.25 g/L. The levels rise 2-fold during inflammation. C1 INH irreversibly binds to and inactivates C1r and C1s proteases in the C1 complex of classical pathway of complement. MASP-1 and MASP-2 proteases in MBL complexes of the lectin pathway are also inactivated. This way, it prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. Although named after its complement inhibitory activity, the protein also inhibits proteases of the fibrinolytic, clotting, and kinin pathways. The protein is the most important physiological inhibitor of plasma kallikrein, fXIa, and fXIIa.

Product Categories/Family for anti-C1 INH antibody

COMPLEMENT

NCBI and Uniprot Product Information

• NCBI GI #: 73858568
• NCBI GeneID: 710
• NCBI Accession #: NP_000053.2
• NCBI GenBank Nucleotide #: NM_000062.2
• UniProt Accession #: P05155; Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2
• Molecular Weight: Predicted MW: 55kDa
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serpin family G member 1
• NCBI Official Symbol: SERPING1
• NCBI Official Synonym Symbols: C1IN; C1NH; HAE1; HAE2; C1INH
• NCBI Protein Information: plasma protease C1 inhibitor
• UniProt Protein Name: Plasma protease C1 inhibitor
• UniProt Gene Name: SERPING1
• UniProt Synonym Gene Names: C1IN; C1NH; C1 Inh; C1Inh

NCBI Description

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Uniprot Description

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.