Complement C1r Enzyme | C1R enzyme
Human Complement C1r
Purity
Greater than 90.0% as determined by SDS-PAGE.
Synonyms
Complement C1r; Human Complement C1r; Complement C1r Human; Complement C1r subcomponent; Complement component 1 subcomponent r; C1R; C1R Human; C1R enzyme
Host
Human Plasma
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
140mM NaCl, 10mM Imidazole and 2mM EDTA, pH7.4.
Sterile Filtered solution.
Sterile Filtered solution.
Human Virus Test
Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I/II, STS and HBSAG.
Preparation and Storage
Human C1r is stable at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen below -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Store, frozen below -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
Related Product Information for C1R enzyme
Introduction: C1r enzyme is the activated form of C1r proenzyme which is inactive zymogen until C1 is activated. C1r is a subunit of the C1 complex which is the first complement component in the classical pathway of complement. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules. Each C1q bindsthe Fc domains of IgG or IgM by using2 or more of its six arms. The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. The activation of C1r results from cleavage of C1r into 2 fragments of 57,000 and 35,000 Dalton.
Description: Human Complement C1r produced in Human plasma having a molecular mass of 92kDa.
Description: Human Complement C1r produced in Human plasma having a molecular mass of 92kDa.
Product Categories/Family for C1R enzyme
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
80,119 Da
NCBI Official Full Name
complement C1r subcomponent
NCBI Official Synonym Full Names
complement component 1, r subcomponent
NCBI Official Symbol
C1R
NCBI Protein Information
complement C1r subcomponent
UniProt Protein Name
Complement C1r subcomponent
Protein Family
UniProt Gene Name
C1R
UniProt Entry Name
C1R_HUMAN
Uniprot Description
C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.41; Protease
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular region
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding
Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation
Disease: Complement Component C1r/c1s Deficiency
Research Articles on C1R
Similar Products
Product Notes
The C1R c1r (Catalog #AAA147346) is an Enzyme produced from Human Plasma and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Complement C1r, Enzyme" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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