Testing Data
(The TFact STAT5A DNA-Binding ELISA detects active STAT5A in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
STAT5A elisa kit
STAT5A TFact DNA-Binding ELISA Kit
Testing Data
(The TFact STAT5A DNA-Binding ELISA detects active STAT5A in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
Testing Data
(The TFact STAT5A DNA-Binding ELISA detects active STAT5A in Hela and HepG2 Nuclear Extract. The Hela and HepG2 cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Uniprot Description
STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytosol; nucleoplasm
Molecular Function: DNA binding; DNA binding transcription factor activity; protein binding; protein tyrosine kinase activity; signal transducer activity
Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; interleukin-7-mediated signaling pathway; isoleucine metabolic process; JAK-STAT cascade; lactation; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; succinate metabolic process; taurine metabolic process; transcription, DNA-dependent; valine metabolic process
Research Articles on STAT5A
Similar Products
Product Notes
The Human, Mouse, Rat STAT5A stat5a (Catalog #AAA9502260) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502260 ELISA Kit recognizes Human, Mouse, Rat STAT5A. It is sometimes possible for the material contained within the vial of "STAT5A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
