AREB6 / ZEB1 Blocking Peptide | ZEB1 blocking peptide
AREB6 / ZEB1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]
Uniprot Description
TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Protein type: DNA-binding; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 10p11.2
Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription factor binding; zinc ion binding
Biological Process: cartilage development; cell proliferation; central nervous system development; embryonic camera-type eye morphogenesis; embryonic skeletal morphogenesis; immune response; negative regulation of cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; pattern specification process; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of mesenchymal cell proliferation; regulation of smooth muscle cell differentiation; regulation of T cell differentiation in the thymus; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; semicircular canal morphogenesis; transcription, DNA-dependent
Disease: Corneal Dystrophy, Fuchs Endothelial, 6; Corneal Dystrophy, Posterior Polymorphous, 3
Research Articles on ZEB1
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Product Notes
The ZEB1 zeb1 (Catalog #AAA425875) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The AREB6 / ZEB1 Immunizing Peptide reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-RPQIRQKI ENKPLQE. It is sometimes possible for the material contained within the vial of "AREB6 / ZEB1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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