GluR7 Antibody | anti-GluR7 antibody

GluR7 Antibody

Cat. Num. AAA853322

• Gene Names: GRM7; GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GluR7; GluR7 Antibody; EAA5; GLR7; GluR7a; dJ1090M5.1 (glutamate receptor; ionotropic; kainate 3 (GLUR7)); excitatory amino acid receptor 5; glutamate receptor 7 precursor; anti-GluR7 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: GluR7 antibody detects endogenous levels of total GluR7 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 915

• Applicable Applications for anti-GluR7 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from human GluR7.
• Preparation and Storage: Store at-20 degree C for 1 year

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR7 antibody (MBS853322).)

Western Blot (WB)

(Western blot analysis of extracts from HuvEc cells, using GluR7 antibody (MBS853322).)

References

Hans H. Schiffer, J. Neurosci., Dec 2000; 20: 9025. Nathalie Strutz, J. Neurosci., Jan 2001; 21: 401. Frédéric Jaskolski, J. Biol. Chem., Jun 2005; 280: 22968-22976. DE Hamassaki-Britto, J. Neurosci., May 1993; 13: 1888.

NCBI and Uniprot Product Information

• NCBI GI #: 4504147
• NCBI GeneID: 2917
• NCBI Accession #: NP_000835.1
• NCBI GenBank Nucleotide #: NM_000844.3
• UniProt Accession #: Q14831; Q8NFS2; Q8NFS3; Q8NFS4
• NCBI Official Full Name: metabotropic glutamate receptor 7 isoform a
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 7
• NCBI Official Symbol: GRM7
• NCBI Official Synonym Symbols: GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
• NCBI Protein Information: metabotropic glutamate receptor 7
• UniProt Protein Name: Metabotropic glutamate receptor 7
• UniProt Gene Name: GRM7
• UniProt Synonym Gene Names: GPRC1G; MGLUR7; mGluR7

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.