Rabbit anti-Human GRM7 Polyclonal Antibody | anti-GRM7 antibody

GRM7 Antibody

Cat. Num. AAA7046244

• Gene Names: GRM7; GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: GRM7; Polyclonal Antibody; GRM7 Antibody; Metabotropic glutamate receptor 7; mGluR7; GPRC1G; MGLUR7; anti-GRM7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 915

• Applicable Applications for anti-GRM7 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Metabotropic glutamate receptor 7 protein (220-410AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47156 / sc-99045
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue MBS7046244 at dilution 1:100)

Related Product Information for anti-GRM7 antibody

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

NCBI and Uniprot Product Information

• NCBI GI #: 4504147
• NCBI GeneID: 2917
• NCBI Accession #: NP_000835.1
• NCBI GenBank Nucleotide #: NM_000844.3
• UniProt Accession #: Q14831; Q8NFS2; Q8NFS3; Q8NFS4
• Molecular Weight: 101,302 Da
• NCBI Official Full Name: metabotropic glutamate receptor 7 isoform a
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 7
• NCBI Official Symbol: GRM7
• NCBI Official Synonym Symbols: GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
• NCBI Protein Information: metabotropic glutamate receptor 7
• UniProt Protein Name: Metabotropic glutamate receptor 7
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM7
• UniProt Synonym Gene Names: GPRC1G; MGLUR7; mGluR7
• UniProt Entry Name: GRM7_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Description

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral to membrane; integral to plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic membrane; receptor complex

Molecular Function: calcium channel regulator activity; glutamate receptor activity; group III metabotropic glutamate receptor activity

Biological Process: behavioral fear response; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of glutamate secretion; regulation of synaptic transmission, glutamatergic; sensory perception of sound; synaptic transmission