Proteinase 3 ELISA Kit | PRTN3 elisa kit
Proteinase 3, Human, ELISA kit
Gene Names
PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
Reactivity
HumanDoes not react: Mouse, Pig, Rat
Synonyms
Proteinase 3; Human; ELISA kit; PR3; PRTN3; Myeloblastin; PR3 Human ELISA kit 1 x 96 det.; PRTN3 elisa kit
Reactivity
Human
Does not react: Mouse, Pig, Rat
Does not react: Mouse, Pig, Rat
Sequence Length
254
Samples
Serum and plasma samples
Preparation and Storage
Product should be stored at 4 degree C.
Under recommended storage conditions, product is stable for at least six months.
Under recommended storage conditions, product is stable for at least six months.
Related Product Information for PRTN3 elisa kit
Intended Uses: The Human Proteinase 3 ELISA kit is to be used for the in vitro quantitative determination of Proteinase 3 in serum and plasma samples. This kit is intended for laboratory research use only. The analysis should be performed by trained laboratory professionals.
Background/Introduction: Proteinase 3 (PR3) is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (so called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. PR3 was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation PR3 can cleave the complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst. PR3 is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Membrane-associated PR3 is also able to activate caspase-3 without triggering apoptosis of neutrophils, which is possibly a neutrophil survival mechanism. In addition, PR3 is involved in myeloid differentiation and is, therefore, also called myeloblastin. PR3 matures/activates major inflammatory cytokines like membrane bound TNF, IL1beta and IL18. It has an important role in inflammasome-independent induction of inflammation and an important role in inflammatory diseases as Reumatoid Arthritis, IBD and inflammatory-associated disease as Type 2 diabetes, cardiovascular diseases and artherosclerosis.
Background/Introduction: Proteinase 3 (PR3) is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (so called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. PR3 was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation PR3 can cleave the complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst. PR3 is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Membrane-associated PR3 is also able to activate caspase-3 without triggering apoptosis of neutrophils, which is possibly a neutrophil survival mechanism. In addition, PR3 is involved in myeloid differentiation and is, therefore, also called myeloblastin. PR3 matures/activates major inflammatory cytokines like membrane bound TNF, IL1beta and IL18. It has an important role in inflammasome-independent induction of inflammation and an important role in inflammatory diseases as Reumatoid Arthritis, IBD and inflammatory-associated disease as Type 2 diabetes, cardiovascular diseases and artherosclerosis.
Product Categories/Family for PRTN3 elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
proteinase 3
NCBI Official Synonym Full Names
proteinase 3
NCBI Official Symbol
PRTN3
NCBI Official Synonym Symbols
MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
NCBI Protein Information
myeloblastin
Protein Family
Research Articles on PRTN3
Similar Products
Product Notes
The Human Does not react: Mouse, Pig, Rat PRTN3 (Catalog #AAA584846) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA584846 ELISA Kit recognizes Human Does not react: Mouse, Pig, Rat PRTN3. It is sometimes possible for the material contained within the vial of "Proteinase 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
