anti-Human, Mouse PIK3R5 Antibody | anti-PIK3R5 antibody

PIK3R5 Antibody

Cat. Num. AAA853408

• Gene Names: PIK3R5; p101; FOAP-2; P101-PI3K; F730038I15Rik
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PIK3R5; PIK3R5 Antibody; Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; PtdIns-3-kinase p101; p101-PI3K; Phosphatidylinositol-4; 5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; anti-PIK3R5 antibody

• Reactivity: Human, Mouse
• Specificity: PIK3R5 antibody detects endogenous levels of total PIK3R5 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 880

• Applicable Applications for anti-PIK3R5 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PIK3R5.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PIK3R5 antibody.)

Product Categories/Family for anti-PIK3R5 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

The MGC Project Team; Genome Res. 14:2121-2127(2004). Sjoeblom T., Science 314:268-274(2006). Suire S., Curr. Biol. 15:566-570(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 217330639
• NCBI GeneID: 23533
• NCBI Accession #: NP_001136105.1
• NCBI GenBank Nucleotide #: NM_001142633.2
• UniProt Accession #: Q8WYR1; Q5G936; Q5G938; Q5G939; Q8IZ23; Q9Y2Y2; B0LPH4; D3DTS3
• Molecular Weight: 54,878 Da
• NCBI Official Full Name: phosphoinositide 3-kinase regulatory subunit 5 isoform 1
• NCBI Official Synonym Full Names: phosphoinositide-3-kinase regulatory subunit 5
• NCBI Official Symbol: PIK3R5
• NCBI Official Synonym Symbols: p101; FOAP-2; P101-PI3K; F730038I15Rik
• NCBI Protein Information: phosphoinositide 3-kinase regulatory subunit 5
• UniProt Protein Name: Phosphoinositide 3-kinase regulatory subunit 5
• Protein Family: Phosphoinositide 3-kinase regulatory
• UniProt Gene Name: PIK3R5
• UniProt Synonym Gene Names: PI3-kinase regulatory subunit 5; PtdIns-3-kinase regulatory subunit

NCBI Description

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Uniprot Description

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG ().