Rabbit GPR170 Polyclonal Antibody | anti-GPR170 antibody

GPR170 polyclonal antibody

Cat. Num. AAA3014860

• Gene Names: PIK3R5; p101; FOAP-2; P101-PI3K; F730038I15Rik
• Reactivity: Human, Rat, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR170; Polyclonal Antibody; GPR170 polyclonal antibody; Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4; 5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K; PIK3R5; anti-GPR170 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PI3K p101 polyclonal antibody detects endogenous levels of PI3K p101 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR170 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human PI3K p101
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of PI3K p101 polyclonal antibody at 1:500 dilutionLaneA: The brain tissue lysate of Rat)

Related Product Information for anti-GPR170 antibody

Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP), and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival. PTEN reverses this process, and research studies have shown that the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. PI3Ks are composed of a catalytic subunit (p110) and a regulatory subunit. Various isoforms of the catalytic subunit (p110alpha, p110beta, p110gamma, and p110delta) have been isolated, and the regulatory subunits that associate with p110alpha, p110beta, and p110delta are p85alpha and p85beta. In contrast, p110gamma associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110gamma is activated by betagamma subunits of heterotrimeric G proteins. The p101 regulatory subunit binds to Gbetagamma, released from heterotrimeric G proteins, and recruits bound p110gamma catalytic subunit to the plasma membrane, which is required for GPCR-induced PI3Kgamma activity.

NCBI and Uniprot Product Information

• NCBI GI #: 217330639
• NCBI GeneID: 23533
• NCBI Accession #: NP_001136105.1
• NCBI GenBank Nucleotide #: NM_001142633.2
• UniProt Accession #: Q8WYR1; Q5G936; Q5G938; Q5G939; Q8IZ23; Q9Y2Y2; B0LPH4; D3DTS3
• Molecular Weight: 97,348 Da
• NCBI Official Full Name: phosphoinositide 3-kinase regulatory subunit 5 isoform 1
• NCBI Official Synonym Full Names: phosphoinositide-3-kinase, regulatory subunit 5
• NCBI Official Symbol: PIK3R5
• NCBI Official Synonym Symbols: p101; FOAP-2; P101-PI3K; F730038I15Rik
• NCBI Protein Information: phosphoinositide 3-kinase regulatory subunit 5; protein FOAP-2; ptdIns-3-kinase p101; PI3-kinase p101 subunit; phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit
• UniProt Protein Name: Phosphoinositide 3-kinase regulatory subunit 5
• UniProt Gene Name: PIK3R5
• UniProt Synonym Gene Names: PI3-kinase regulatory subunit 5
• UniProt Entry Name: PI3R5_HUMAN

NCBI Description

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Uniprot Description

PIK3R5: Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytoplasm; cytosol; nucleus

Molecular Function: G-protein beta/gamma-subunit binding; 1-phosphatidylinositol-3-kinase regulator activity

Biological Process: positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; platelet activation; phosphoinositide 3-kinase cascade; phospholipid metabolic process; phosphatidylinositol biosynthetic process; blood coagulation; regulation of phosphoinositide 3-kinase activity

Disease: Ataxia-oculomotor Apraxia 3