Testing Data
(Images: JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.)
anti-Human, Mouse JARID2 Antibody | anti-JARID2 antibody
JARID2, Affinity Purified Antibody, Rabbit
Testing Data
(Images: JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.)
Testing Data
(Images: JARID2 staining of HeLa cells using a DyLight 488 conjugated secondary antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Uniprot Description
JARID2: a Polycomb protein required for neural tube formation. Contains a Jumonji C domain but lacks histone demethylase activity. Essential for normal heart development and function. Required for embryonic viability. Down-regulation of Jarid2 impairs ES cell differentiation and Oct4 silencing. Associates with the Polycomb-Repressive Complex 2 (PRC2), stimulating PRC2 methyltransferase activity. PRC2 includes the histone H3 Lys 27 (H3K27) methyltransferase Ezh2, EED, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The recruitment of PRC2 to a promoter leads to increased levels of di- and trimethylation of H3K27 (H3K27me2/3), regulating the balance between self-renewal and differentiation of embryonic stem cells. The ability of Jarid 2 to be recruited to DNA in ES cells is interdependent on PRC2. Its knockdown reduces PRC2 at its target promoters, while ES cells lacking the PRC2 component EED are deficient in Jarid2 promoter activity. Acts as a transcriptional repressor of ANF by binding to both GATA4 and NKX2-5 and repressing their transcriptional activator activities. Participates in the negative regulation of cell proliferation signaling. Interacts with the N-terminal region of GATA4 and the C- terminal region of the NKX2-5 homeobox and represses their ability to activate transcription of ANF.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 6p24-p23
Cellular Component: nucleoplasm; histone methyltransferase complex; ESC/E(Z) complex; nucleus
Molecular Function: histone demethylase activity; DNA binding; chromatin binding
Biological Process: spleen development; positive regulation of histone H3-K9 methylation; central nervous system development; thymus development; transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; stem cell differentiation; liver development; negative regulation of histone methylation; regulation of gene expression, epigenetic; negative regulation of cell proliferation; negative regulation of gene expression, epigenetic; gene expression; negative regulation of transcription, DNA-dependent
Research Articles on JARID2
Similar Products
Product Notes
The JARID2 jarid2 (Catalog #AAA555101) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The JARID2, Affinity Purified Antibody, Rabbit reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's JARID2 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the JARID2 jarid2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JARID2, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
