Human TLR8 (Toll-Like Receptor 8) ELISA Kit | TLR8 elisa kit

Human TLR8 (Toll-Like Receptor 8) ELISA Kit

Cat. Num. AAA7608063

• Gene Names: TLR8; CD288
• Reactivity: Human
• Synonyms: TLR8 (Toll-Like Receptor 8); Human TLR8 (Toll-Like Receptor 8) ELISA Kit; CD288; TLR8; Toll-like receptor 8; TLR8 elisa kit

• Reactivity: Human
• Sequence Length: 1041

• Assay Type: Sandwich ELISA, Double Antibody
• Samples: TLR8 ELISA Kit allows for the in vitro quantitative determination of TLR8 concentrations in plasma, tissue homogenates and other biological fluids.
• Detection Range: 0.156-10ng/ml
• Sensitivity: 0.094ng/ml
• Intra Assay: CV<8%
• Inter Assay: CV<10%
• Preparation and Storage: Store at 4 degree C for 6 months.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 20302168
• NCBI GeneID: 51311
• NCBI Accession #: NP_619542.1
• NCBI GenBank Nucleotide #: NP_619542.1
• UniProt Accession #: Q9NR97
• NCBI Official Full Name: toll-like receptor 8 isoform 2
• NCBI Official Synonym Full Names: toll like receptor 8
• NCBI Official Symbol: TLR8
• NCBI Official Synonym Symbols: CD288
• NCBI Protein Information: toll-like receptor 8
• UniProt Protein Name: Toll-like receptor 8
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR8
• UniProt Entry Name: TLR8_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane

Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; drug binding; receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; immunoglobulin mediated immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process