Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (PREX2) Standard Curve.)
Human Phosphatidylinositol 3, 4, 5-Trisphosphate-Dependent Rac Exchanger 2 Protein (PREX2) ELISA Kit | PREX2 elisa kit
Human Phosphatidylinositol 3, 4, 5-Trisphosphate-Dependent Rac Exchanger 2 Protein (PREX2) ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (PREX2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (PREX2) Standard Curve.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
Uniprot Description
PREX2: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; Phosphatase, regulatory subunit; GEFs
Chromosomal Location of Human Ortholog: 8q13.2
Cellular Component: intracellular; plasma membrane
Molecular Function: GTPase activator activity; Rac guanyl-nucleotide exchange factor activity
Biological Process: adult locomotory behavior; dendrite morphogenesis; G-protein coupled receptor protein signaling pathway; phosphoinositide 3-kinase cascade; positive regulation of GTPase activity; regulation of Rho protein signal transduction
Research Articles on PREX2
Similar Products
Product Notes
The Human PREX2 prex2 (Catalog #AAA9714834) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714834 ELISA Kit recognizes Human PREX2. It is sometimes possible for the material contained within the vial of "Phosphatidylinositol 3, 4, 5-Trisphosphate-Dependent Rac Exchanger 2 Protein (PREX2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
