Human Nanos Homolog 1 (NANOS1) ELISA Kit | NANOS1 elisa kit
Human Nanos Homolog 1 (NANOS1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Background: NANOS1 encodes a CCHC-type zinc finger protein that is a member of the nanos family. Nanos homolog 1 co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in NANOS1 are associated with spermatogenic impairment.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
Uniprot Description
NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component: perinuclear region of cytoplasm; cytoplasm
Molecular Function: protein binding; translation repressor activity; zinc ion binding; RNA binding
Biological Process: cell migration; negative regulation of translation
Disease: Spermatogenic Failure 12
Research Articles on NANOS1
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Product Notes
The Human NANOS1 nanos1 (Catalog #AAA9715042) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715042 ELISA Kit recognizes Human NANOS1. It is sometimes possible for the material contained within the vial of "Nanos Homolog 1 (NANOS1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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