Human BLC-1/CXCL13 ELISA Kit | BLC-1/CXCL13 elisa kit

Human BLC-1/CXCL13 ELISA Kit

Cat. Num. AAA3800077

• Gene Names: CXCL13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• Reactivity: Human
• Synonyms: BLC-1/CXCL13; Human BLC-1/CXCL13 ELISA Kit; BLC-1/CXCL13 elisa kit

• Reactivity: Human
• Sequence Length: 109

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 10 pg/ml-160 pg/ml
• Sensitivity: 1 pg/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for BLC-1/CXCL13 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofBLC-1;CXCL13in the sample, This BLC-1;CXCL13 ELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus BLC-1;CXCL13concentration. The concentration of BLC-1;CXCL13in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 5453577
• NCBI GeneID: 10563
• NCBI Accession #: NP_006410.1
• NCBI GenBank Nucleotide #: NP_006410.1
• UniProt Accession #: O43927
• NCBI Official Full Name: C-X-C motif chemokine 13
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 13
• NCBI Official Symbol: CXCL13
• NCBI Official Synonym Symbols: BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• NCBI Protein Information: C-X-C motif chemokine 13
• UniProt Protein Name: C-X-C motif chemokine 13
• UniProt Gene Name: CXCL13
• UniProt Synonym Gene Names: BCA1; BLC; SCYB13; BCA-1
• UniProt Entry Name: CXL13_HUMAN

NCBI Description

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

Uniprot Description

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; positive regulation of integrin activation; lymph node development; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response