Human Atonal Homolog 1 (ATOH1) ELISA Kit | ATOH1 elisa kit
Human Atonal Homolog 1 (ATOH1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Uniprot Description
ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.
Protein type: DNA-binding; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: nucleus
Molecular Function: protein dimerization activity; chromatin DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; central nervous system development; auditory receptor cell fate determination; neuron migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of apoptosis
Research Articles on ATOH1
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Product Notes
The Human ATOH1 atoh1 (Catalog #AAA9304243) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9304243 ELISA Kit recognizes Human ATOH1. It is sometimes possible for the material contained within the vial of "Atonal Homolog 1 (ATOH1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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